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klf11 gene single nucleotide polymorphisms (snps)  (PopulationGenetics)

 
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    PopulationGenetics klf11 gene single nucleotide polymorphisms (snps)
    Biological function of KLFs in the nervous system
    Klf11 Gene Single Nucleotide Polymorphisms (Snps), supplied by PopulationGenetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/klf11+gene+single+nucleotide+polymorphisms+(snps)/klf11+gene/pmc04113556-119-34-29
    Average 90 stars, based on 1 article reviews
    klf11 gene single nucleotide polymorphisms (snps) - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Krüpple-like factors in the central nervous system: novel mediators in Stroke"

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke

    Journal: Metabolic brain disease

    doi: 10.1007/s11011-013-9468-1

    Biological function of KLFs in the nervous system
    Figure Legend Snippet: Biological function of KLFs in the nervous system

    Techniques Used: Migration, Activation Assay

    Schematic representation of stroke-associated KLFs and signaling cascades. KLF4 is induced in reactive astrocytes in rat hippocampus after global cerebral ischemia, and may transcriptionally regulate astroglial reaction and cerebral inflammation following ischemic injury (Park et al., 2013). KLF2 level is decreased in blood outgrowth endothelial cells (BOECs) derived from stroke children with sickle cell anemia (SCA) than in non-SCA BOECs, thus changes the ratio between proinflammatory NF-κB/p65 to anti-inflammatory factor KLF2 and leads to a proinflammatory phenotype within the cerebral vasculature (Enenstein et al., 2010). In mouse brain vasculature, ischemic stimuli induce KLF2 (Shi et al., 2013) or KLF11 dysfunction (Yin et al., 2013), featuring attenuated KLF2 transactivation of tight junction protein occludin or reduced KLF11-mediated PPARγ vascular function, thereby resulting in a series of cerebral vascular pathologies, such as BBB damage/dysfunction, disturbed cerebral vascular protection, and final neuronal cell death.
    Figure Legend Snippet: Schematic representation of stroke-associated KLFs and signaling cascades. KLF4 is induced in reactive astrocytes in rat hippocampus after global cerebral ischemia, and may transcriptionally regulate astroglial reaction and cerebral inflammation following ischemic injury (Park et al., 2013). KLF2 level is decreased in blood outgrowth endothelial cells (BOECs) derived from stroke children with sickle cell anemia (SCA) than in non-SCA BOECs, thus changes the ratio between proinflammatory NF-κB/p65 to anti-inflammatory factor KLF2 and leads to a proinflammatory phenotype within the cerebral vasculature (Enenstein et al., 2010). In mouse brain vasculature, ischemic stimuli induce KLF2 (Shi et al., 2013) or KLF11 dysfunction (Yin et al., 2013), featuring attenuated KLF2 transactivation of tight junction protein occludin or reduced KLF11-mediated PPARγ vascular function, thereby resulting in a series of cerebral vascular pathologies, such as BBB damage/dysfunction, disturbed cerebral vascular protection, and final neuronal cell death.

    Techniques Used: Derivative Assay

    KLFs involved in neurological disorders
    Figure Legend Snippet: KLFs involved in neurological disorders

    Techniques Used: Expressing, Over Expression, Activation Assay, Transmission Assay

    Related Articles

    Expressing:

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke
    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Migration:

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke
    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Activation Assay:

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke
    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Derivative Assay:

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke
    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Over Expression:

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke
    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Transmission Assay:

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke
    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).



    Similar Products

    klf11 gene single nucleotide polymorphisms (snps)  (PopulationGenetics)
    90
    PopulationGenetics klf11 gene single nucleotide polymorphisms (snps)
    Biological function of KLFs in the nervous system
    Klf11 Gene Single Nucleotide Polymorphisms (Snps), supplied by PopulationGenetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/klf11+gene+single+nucleotide+polymorphisms+(snps)/klf11+gene/pmc04113556-119-34-29
    Average 90 stars, based on 1 article reviews
    klf11 gene single nucleotide polymorphisms (snps) - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Biological function of KLFs in the nervous system

    Journal: Metabolic brain disease

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke

    doi: 10.1007/s11011-013-9468-1

    Figure Lengend Snippet: Biological function of KLFs in the nervous system

    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Techniques: Migration, Activation Assay

    Schematic representation of stroke-associated KLFs and signaling cascades. KLF4 is induced in reactive astrocytes in rat hippocampus after global cerebral ischemia, and may transcriptionally regulate astroglial reaction and cerebral inflammation following ischemic injury (Park et al., 2013). KLF2 level is decreased in blood outgrowth endothelial cells (BOECs) derived from stroke children with sickle cell anemia (SCA) than in non-SCA BOECs, thus changes the ratio between proinflammatory NF-κB/p65 to anti-inflammatory factor KLF2 and leads to a proinflammatory phenotype within the cerebral vasculature (Enenstein et al., 2010). In mouse brain vasculature, ischemic stimuli induce KLF2 (Shi et al., 2013) or KLF11 dysfunction (Yin et al., 2013), featuring attenuated KLF2 transactivation of tight junction protein occludin or reduced KLF11-mediated PPARγ vascular function, thereby resulting in a series of cerebral vascular pathologies, such as BBB damage/dysfunction, disturbed cerebral vascular protection, and final neuronal cell death.

    Journal: Metabolic brain disease

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke

    doi: 10.1007/s11011-013-9468-1

    Figure Lengend Snippet: Schematic representation of stroke-associated KLFs and signaling cascades. KLF4 is induced in reactive astrocytes in rat hippocampus after global cerebral ischemia, and may transcriptionally regulate astroglial reaction and cerebral inflammation following ischemic injury (Park et al., 2013). KLF2 level is decreased in blood outgrowth endothelial cells (BOECs) derived from stroke children with sickle cell anemia (SCA) than in non-SCA BOECs, thus changes the ratio between proinflammatory NF-κB/p65 to anti-inflammatory factor KLF2 and leads to a proinflammatory phenotype within the cerebral vasculature (Enenstein et al., 2010). In mouse brain vasculature, ischemic stimuli induce KLF2 (Shi et al., 2013) or KLF11 dysfunction (Yin et al., 2013), featuring attenuated KLF2 transactivation of tight junction protein occludin or reduced KLF11-mediated PPARγ vascular function, thereby resulting in a series of cerebral vascular pathologies, such as BBB damage/dysfunction, disturbed cerebral vascular protection, and final neuronal cell death.

    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Techniques: Derivative Assay

    KLFs involved in neurological disorders

    Journal: Metabolic brain disease

    Article Title: Krüpple-like factors in the central nervous system: novel mediators in Stroke

    doi: 10.1007/s11011-013-9468-1

    Figure Lengend Snippet: KLFs involved in neurological disorders

    Article Snippet: It is worth noting that KLF11 is a member of the KLF family with high expression in vascular endothelium ( Fan et al., 2012 ), and emerging data from population genetics studies suggest that KLF11 gene single nucleotide polymorphisms (SNPs) are significantly associated with type 2 diabetes ( Neve et al., 2005 ; Fernandez-Zapico et al., 2009 ).

    Techniques: Expressing, Over Expression, Activation Assay, Transmission Assay